Related Experiment Video
Updated: May 16, 2026
03:45
Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
Published on: August 8, 2022
Bridging the Gap Between Genetic Cardiomyopathies and Pregnancy
Karen Flores Rosario1, Merna Hussien1, Phoenix Grover1
1Division of Cardiology, Department of Medicine, Duke University Hospital, Durham, North Carolina, USA.
JACC. Advances
|May 14, 2026
Summary
Genetic testing identifies more women of childbearing potential with cardiomyopathy and arrhythmia genes. This knowledge aids reproductive planning and guides interventions to reduce pregnancy risks for these women.
Area of Science:
- Cardiology
- Genetics
- Reproductive Medicine
Background:
- Genetic testing for cardiomyopathies and arrhythmias is increasing.
- Cascade screening identifies relatives with pathogenic variants.
- More women of childbearing potential are identified as genotype-positive.
Purpose of the Study:
- To outline the landscape of genetic cardiomyopathies.
- To discuss pregnancy considerations for affected women.
- To review counseling and management strategies.
Main Methods:
- Review of current genetic cardiomyopathies.
- Examination of pregnancy risk stratification models.
- Discussion of preconception, antenatal, and postpartum care.
Main Results:
- Genotype knowledge impacts reproductive planning and risk reduction.
- Existing risk models have limitations.
- Multidisciplinary Pregnancy Heart Teams improve outcomes.
Conclusions:
- Genotype-positive women require specialized preconception counseling.
- Antenatal surveillance and delivery planning are crucial.
- Postpartum management is essential for maternal and fetal well-being.
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