Impaired Self-Other Voice Discrimination in Patients with Auditory-Verbal Hallucinations and Nonclinical...

Auditory-verbal hallucinations (AVH), hearing voices without external speakers, are a core symptom of schizophrenia. A prominent account proposes that AVH reflect failures to recognize self-generated speech. Similar effects in hallucination-prone individuals suggest that these mechanisms span a continuum from subclinical to clinical manifestations. We used a Self-Other Voice Discrimination (SOVD) task, previously identified as a potential biomarker of self-disturbance, to assess self-recognition deficits in patients with (AVH+) and without (AVH-) a history of AVH, as well as in healthy individuals.

Forty-one schizophrenia patients (23 AVH+, 18 AVH-) and 40 healthy controls completed the SOVD task. In a follow-up experiment, 26 additional healthy participants performed a familiar-other voice discrimination task identical to SOVD, but without the self-voice. In patients, performance was tested in relation to symptom severity (Positive and Negative Syndrome Scale [PANSS]), and in controls to hallucination proneness scores.

SOVD performance was selectively impaired in AVH+ patients, while AVH- patients did not substantially differ from controls. Across groups, higher PANSS and hallucination proneness scores were specifically related to reduced self-voice recognition, with no impact on other-voice recognition. This effect did not extend to familiar-other voice discrimination.

Impaired self-voice recognition is a promising selective marker of a history of AVH in schizophrenia occurrence in the acute phase of schizophrenia and extends to hallucination proneness in the general population. These findings support a dimensional view of hallucinations and point to deficits specific to self-voice processing rather than general voice perception. They also highlight SOVD as a promising cognitive biomarker of AVH, with direct implications for early identification and targeted interventions.