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Drop-Shaped Optical Microfiber Enabled Biomechanical Sensor.

Yan Xu1, Xitao Tu1, Haochen Jiang2

  • 1State Key Laboratory of Extreme Photonics and Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|May 14, 2026
PubMed
Summary

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This summary is machine-generated.

Researchers developed a novel microforce sensor using an optical microfiber for precise biomechanical measurements on living organisms. This sensor achieves nanonewton-level force resolution, overcoming limitations of existing technologies.

Area of Science:

  • Biophysics
  • Optical Engineering
  • Materials Science

Background:

  • Microforce sensing is crucial in biomechanics but current sensors have operational and flexibility limitations for in-vivo applications.
  • Existing methods struggle with precision and potential contamination when measuring forces on delicate biological samples.

Purpose of the Study:

  • To develop a novel microforce sensor with enhanced sensitivity and flexibility for biomechanical characterization of living organisms.
  • To overcome the limitations of existing microforce sensors, enabling precise nanonewton-level force measurements.

Main Methods:

  • Fabrication of a microforce sensor utilizing a drop-shaped optical microfiber with a small bending radius.
  • Integration of a PDMS microsphere at the sensor tip to prevent contamination and enhance sensitivity.
Keywords:
C. elegansYoung's modulusbiomechanicsmicroforce sensoroptical microfibersingle cell

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  • Monitoring output light intensity variations to measure applied microforces.

    • Main Results:

    • The developed sensor achieves a force resolution of 24 nN within a 0-10 µN range.
    • Demonstrated proof-of-concept for Young's modulus characterization of onion epidermal cells and Caenorhabditis elegans.
    • The sensor exhibits a small footprint, low spring constant, and high sensitivity.

    Conclusions:

    • The optical microfiber-based microforce sensor offers a precise, flexible, and reliable solution for biomechanical characterization.
    • The sensor design is adaptable for various applications requiring sensitive microforce detection.
    • This technology advances in-vivo biomechanical sensing capabilities.