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Updated: May 16, 2026

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06:02

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Published on: June 10, 2016

Macrophage-to-Myofibroblast Transdifferentiation Contributes to Pulmonary Fibrosis via the MERTK-SPP1-SRC-TKS5

Yungeng Wei1, Hua Guo1, Xiangsheng Yang1

  • 1State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|May 14, 2026
PubMed
Summary

Macrophage-to-myofibroblast transdifferentiation (MMT) drives pulmonary fibrosis. Targeting the MERTK-SPP1-SRC-TKS5 pathway suppresses MMT and fibrosis progression, offering a new therapeutic strategy.

Keywords:
MERTKTKS5idiopathic pulmonary fibrosismacrophagemacrophage‐to‐myofibroblast transdifferentiation (MMT)

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