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Dermatologic Toxicities Induced by JAK Inhibitors
Luca Rapparini1,2, Michela Starace3,4, Zoe Apalla5
1Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy. luca.rapparini2@studio.unibo.it.
American Journal of Clinical Dermatology
|May 14, 2026
Summary
Janus kinase (JAK) inhibitors can cause skin issues like acne and infections, but these are usually manageable. Early recognition and dermatologic care are key for patients on JAK inhibitors.
Area of Science:
- Dermatology
- Immunology
- Pharmacology
Background:
- Janus kinase (JAK) inhibitors are widely used for immune-mediated diseases.
- Growing use necessitates understanding their safety, especially cutaneous adverse events.
Purpose of the Study:
- To review dermatologic toxicities of systemic and topical JAK inhibitors.
- To inform clinical management and patient adherence.
Main Methods:
- Narrative review of current evidence.
- Focused on dermatologic adverse events associated with JAK inhibitors.
Main Results:
- Acne-like eruptions are the most common side effect, showing dose-dependency.
- Cutaneous infections, particularly herpes zoster, are significant.
- Non-melanoma skin cancers are less frequent but noted, especially with ruxolitinib in hematologic patients.
Conclusions:
- Dermatologic adverse events from JAK inhibitors are generally manageable.
- Early recognition and dermatologic management are crucial for treatment adherence.
- Awareness of these side effects supports safe JAK inhibitor use.
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