Related Experiment Video
Updated: May 16, 2026

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
Published on: March 3, 2023
Aeroallergens in Atopic Dermatitis and Chronic Urticaria
Sonam Sani1, Esther Ro2, Aparna Tatineni2
1Division of Rheumatology, Allergy and Immunology, NYU Grossman Long Island School of Medicine, 1111 Franklin Avenue , Garden City, 11530, New York, USA. Sonam.Sani@nyulangone.org.
Purpose Of Review:
Aeroallergens are well established triggers of allergic rhinitis and asthma, yet their contribution to allergic skin diseases such as atopic dermatitis (AD) and chronic urticaria (CU) remains incompletely understood. This article reviews the molecular basis of aeroallergen-driven skin disease in AD and CU as well as management strategies.
Recent Findings:
Aeroallergen triggered skin disease involves epithelial barrier disruption, innate immune activation, and neuroimmune amplification. Allergen disruption of the epithelial barrier through PAR-2 and TLR-mediated signaling, induces alarmins that sustain an IL-31-driven itch-scratch cycle. Biologics targeting these pathways reshape these cytokine networks, while checkpoint inhibitors show promise for durable remission. In CU, house dust mite sensitization correlates with basophil hyperreactivity and greater disease severity. Aeroallergen triggered inflammation involves overlapping barrier dysfunction, innate immune activation, and neuroimmune pathways that extend beyond traditional IgE-mediated allergic responses. Future research should prioritize endotype-based patient stratification and quantify the impact of aeroallergen exposure on chronic skin disease trajectory.
Related Concept Videos
Allergic Reactions: Anaphylaxis
Allergic Reactions
Asthma I: Introduction
Drug Toxicity: Allergic Reactions
Allergic Drug Reactions
Asthma: Pathogenesis and Management
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

