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Synergistic Catalysis: Integrating Acids, Metals, and Light in Nature-Inspired Asymmetric Multicomponent Synthesis
Aeyaz Ahmad Bhat1, Magdi E A Zaki2, Amel Gacem3,4
1Department of Chemistry, School of Chemical Engineering and Physical Sciences, Lovely Professional University, Phagwara, Punjab, India. aeyazbhatchem@gmail.com.
Topics in Current Chemistry (Cham)
|May 14, 2026
Summary
Recent advances in asymmetric multicomponent reactions (AMCRs) utilize chiral phosphoric acids, transition metal complexes, and photoredox catalysis. This review covers progress from 2019-2025, focusing on enantioselective bond formation and mechanistic insights.
Area of Science:
- Organic Chemistry
- Catalysis
- Synthetic Chemistry
Background:
- Asymmetric catalysis has advanced significantly due to new catalysts like chiral phosphoric acids, transition metal complexes, and photoredox systems.
- Asymmetric multicomponent reactions (AMCRs) are key for constructing complex molecules efficiently and selectively.
Purpose of the Study:
- To review recent progress (2019-2025) in AMCRs.
- To highlight the roles of chiral phosphoric acids, transition metal complexes, and photoredox systems in AMCRs.
- To analyze mechanistic features for a unified understanding of reactivity and selectivity.
Main Methods:
- Focus on AMCRs catalyzed by chiral phosphoric acids, photoredox systems, Lewis acids/bases, and transition metals.
- Analysis of catalyst interplay, activation modes, and stereocontrol.
- Integration of light-driven processes with chiral induction.
Main Results:
- Demonstration of distinct yet cooperative roles of different catalytic platforms in enantioselective bond formation.
- Comprehensive overview of AMCRs, discussing mechanistic features and stereocontrol.
- Identification of emerging strategies integrating photoredox catalysis with chiral induction.
Conclusions:
- Modern AMCR design is underpinned by well-defined catalytic principles.
- Advances in asymmetric catalysis provide a versatile platform for synthesizing complex molecules.
- The integration of various catalytic systems enhances efficiency and selectivity in AMCRs.
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