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Related Concept Videos

Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...

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Related Experiment Video

Updated: May 16, 2026

High Throughput Sequential ELISA for Validation of Biomarkers of Acute Graft-Versus-Host Disease
09:00

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Published on: October 31, 2012

A Pre-Kidney Transplant Blood-Based Next-Generation Sequencing Assay to Predict Early Acute Rejection.

Beatrice P Concepcion1, Oriol Bestard2, Milagros Samaniego-Picota3

  • 1University of Chicago, Chicago, IL, USA.

Kidney360
|May 14, 2026
PubMed
Summary

A new pre-transplant risk assessment (PTRA) test accurately identifies kidney transplant recipients at high risk for early acute rejection. This transcriptomic profile improves graft health predictions and personalized treatment strategies.

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Non-invasive Imaging of Acute Allograft Rejection after Rat Renal Transplantation Using 18F-FDG PET
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Last Updated: May 16, 2026

High Throughput Sequential ELISA for Validation of Biomarkers of Acute Graft-Versus-Host Disease
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Non-invasive Imaging of Acute Allograft Rejection after Rat Renal Transplantation Using 18F-FDG PET
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Non-invasive Imaging of Acute Allograft Rejection after Rat Renal Transplantation Using 18F-FDG PET

Published on: April 28, 2013

Area of Science:

  • Transplantation immunology
  • Genomic medicine
  • Biomarker discovery

Background:

  • Traditional methods for predicting kidney graft failure have limitations in identifying early acute rejection.
  • Next-generation sequencing (NGS) offers potential for pre-transplant immunologic profiling.

Purpose of the Study:

  • To develop and validate a novel NGS assay to predict early acute rejection in kidney transplant recipients.
  • To assess the efficacy of the pre-transplant risk assessment (PTRA™) test.

Main Methods:

  • A prospective, international study with 321 kidney transplant participants.
  • Peripheral blood and biopsy samples analyzed using a 29-gene signature algorithm (PTRA™).
  • Clinical validation performed on 122 deceased donor kidney transplant recipients.

Main Results:

  • PTRA™ classified 25% of recipients as high-risk for early acute rejection.
  • High-risk patients had a 19% rate of early acute rejection versus 3% in low-risk patients.
  • PTRA™ demonstrated an AUC of 0.78 for predicting early acute rejection within 60 days post-transplant.

Conclusions:

  • The PTRA™ test effectively stratifies kidney transplant recipients by early acute rejection risk.
  • Pre-transplant transcriptomic profiling has implications for optimizing graft health and personalized patient management.