Related Experiment Video
Updated: May 16, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
IgG4-related disease overlapping with systemic lupus erythematosus
Teodora Baciu1,2,3, Diana Mazilu3,4, Andra Balanescu3,4
1IRMB, University of Montpellier, INSERM, CHU Montpellier, Montpellier, France.
None:
We report two cases of overlap syndrome between IgG4-related disease (IgG4-RD) and systemic lupus erythematosus (SLE), encountered in distinct rheumatology centres in France and Romania. The co-occurrence of SLE and IgG4-RD is rare, and both cases highlight the intersection of these autoimmune conditions. The overlapping features of both diseases present a diagnostic challenge but offer an opportunity for a greater understanding of the pathophysiological interactions between IgG4-RD and SLE. Clinicians must be vigilant in distinguishing between these entities, as they carry different therapeutic implications.
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