The miR-1260-ZNF axis in non-small cell lung cancer: Focus on ZNF302, ZNF439, and ZNF781

Non-small cell lung cancer (NSCLC), a leading cause of cancer-related mortality, requires the identification of novel biomarkers for early detection and therapeutic intervention. In this study, we explored the regulatory interactions between miR-1260 and zinc finger (ZNF) family genes within the NSCLC microenvironment to determine their roles as diagnostic and prognostic indicators. Through bioinformatics analysis of public datasets from the GEO database, the expression patterns and prognostic significance of miR-1260 and ZNF genes were systematically evaluated. Tools, such as GEO 2 R and the Weishengxin platform, were used for data processing and visualization to construct a comprehensive miRNA-mRNA regulatory network. The results revealed distinct expression profiles of miR-1260 and ZNF genes in NSCLC tissues compared to their normal counterparts, with significant correlations with patient survival outcomes. These findings not only highlight the potential of miR-1260 and ZNF genes as diagnostic biomarkers but also suggest that their therapeutic targeting could offer new strategies for NSCLC management. This study emphasized the importance of the miR-1260-ZNF regulatory axis in NSCLC pathogenesis, positioning these molecules as promising candidates for diagnosis, prognosis, and further clinical validation. Future research should focus on mechanistic exploration and large-scale clinical trials to translate these insights into improved oncological treatment protocols.