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This is IT: How accelerated intermittent theta burst stimulation relieves depression symptoms

Morteza Salimi1, Dhakshin S Ramanathan2

  • 1Research Service, VA San Diego Healthcare System, La Jolla, CA 92161, USA; NEATLabs, Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA.

Cell
|May 14, 2026
PubMed

In this issue of Cell, Gongwer et al.1 and Johnson et al.2 identify the plasticity of intratelencephalic (IT) neuronal projections to anterior insula as a central substrate mediating the antidepressant effects of accelerated intermittent theta burst stimulation. These studies suggest a revolutionary future in which brain stimulation can enable circuit-specific plasticity.

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