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Related Experiment Video

Updated: May 16, 2026

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
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Published on: April 28, 2023

Is weight cycling clinically harmful?

Faidon Magkos1, Norbert Stefan2

  • 1Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.

The Lancet. Diabetes & Endocrinology
|May 14, 2026
PubMed
Summary
This summary is machine-generated.

Weight cycling, or repeated weight loss and regain, does not causally harm people with obesity. The health benefits of intermittent weight reduction outweigh potential risks of weight fluctuation.

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Area of Science:

  • Metabolic Health
  • Obesity Research
  • Body Composition

Background:

  • Weight cycling is common, with many attempting weight loss.
  • Concerns exist that weight cycling may harm metabolism and body composition.
  • Potential risks include increased fat mass, decreased lean mass, and exacerbated obesity.

Purpose of the Study:

  • To critically evaluate evidence on weight cycling's effects.
  • To investigate impacts on bodyweight, composition, and metabolism.
  • To discuss strategies for mitigating weight regain.

Main Methods:

  • Review of human and animal studies.
  • Critical evaluation of existing research.
  • Discussion of potential confounding factors.

Main Results:

  • Current evidence does not support a causal link between weight cycling and clinical harm.
  • Adverse effects are likely circumstantial, not directly caused by weight cycling.
  • Benefits of intermittent weight reduction appear to outweigh risks.

Conclusions:

  • Weight cycling per se is not clinically harmful in individuals with obesity.
  • Observed adverse effects may be due to other factors like aging or cumulative obesity.
  • Intermittent weight reduction offers benefits that exceed potential risks of weight fluctuation.