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The MPLEx Protocol for Multi-omic Analyses of Soil Samples
Published on: May 30, 2018
Microbial dysbiosis in metabolic disorders: linking epigenomic regulation and pathological mechanisms
Arun K Sharma1, Md Sayeed Akhtar2, Khalid Orayj2
1Department of Pharmacology, Amity Institute of Pharmacy, Amity University Haryana, Gurugram, Haryana 122413, India.
Abstract:
Microbial dysbiosis critically contributes to metabolic disorders by altering host-microbiome interactions and disrupting metabolic homeostasis. This review highlights how dysbiosis-derived metabolites, including short-chain fatty acids (SCFA) and trimethylamine-N-oxide (TMAO), modulate epigenetic mechanisms such as DNA methylation, histone modification, and non-coding RNA expression in key metabolic tissues. These epigenomic changes impair insulin signaling, lipid metabolism, and inflammatory responses. We further explore the potential of microbial-epigenetic biomarkers for early diagnosis of metabolic disease. Moreover, we assess emerging microbiome-based therapies including prebiotics, SCFA supplementation, and fecal microbiota transplantation for their ability to reverse epigenetic dysregulation. Understanding the microbiome-epigenome-metabolism axis may enable precision diagnostics and targeted interventions for obesity, type 2 diabetes, and related disorders.
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