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The role of macrophage senescence in cardiovascular diseases

Yuting Sun1, Yingxin Chang1, Hanqing Lin1

  • 1First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China; National Clinical Research Center for Chinese Medicine, Tianjin, China; State Key Laboratory of Modern Chinese Medicine, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae for the Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Cellular Signalling
|May 14, 2026
PubMed

Insights

Macrophage senescence, a key aging process, drives cardiovascular diseases (CVDs). Targeting senescent macrophages offers a promising therapeutic strategy for preventing and treating age-related heart conditions.

Area of Science:

  • Cellular senescence
  • Cardiovascular biology
  • Immunogerontology

Background:

  • Macrophage senescence significantly contributes to organismal aging.
  • It acts as a pathological link between aging and cardiovascular diseases (CVDs).

Purpose of the Study:

  • To review molecular mechanisms of macrophage senescence.
  • To explore the link between macrophage senescence and CVDs.
  • To summarize senescence-targeted macrophage therapies for CVDs.

Main Methods:

  • Literature review on molecular mechanisms.
  • Analysis of associations between macrophage senescence and CVDs.
  • Systematic summary of therapeutic strategies.

Main Results:

  • Key mechanisms include DNA damage, telomere attrition, mitochondrial dysfunction, oxidative stress, and immune dysregulation.
  • Macrophage senescence is intrinsically linked to atherosclerosis, myocardial infarction, and chronic heart failure.
  • Senescence-targeted therapies show potential for CVD prevention and treatment.

Conclusions:

  • Macrophage senescence is a critical factor in aging and CVD development.
  • Understanding these mechanisms is vital for developing new treatments.
  • Targeting macrophage senescence offers a promising avenue for cardiovascular health.
Keywords:
AgingAtherosclerosisCVDsInflammationSASPSignaling pathways

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