Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Disorders of the Male Reproductive System

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...

Positron Emission Tomography

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Mapping the Multidimensional Stress Burden in Nursing Students: A Systematic Review and Instrument-Specific Meta-Analysis.

Nursing research and practice·2026

Same author

An artificial intelligence model integrating clinico-laboratory data and single nucleotide polymorphism-based genomic risk for prostate cancer diagnosis in Korean men.

Investigative and clinical urology·2026

Same author

Predictors of benign histology in clinical T1a small renal masses: A large multicenter cohort study.

Investigative and clinical urology·2026

Same author

Therapeutic use of cold-stored platelets in humans: protocol for a systematic review and meta-analysis.

BMJ open·2026

Same author

Walking and Health Outcomes in Older Adults: A Systematic Review and Meta-Analysis of Longitudinal Studies.

American journal of health promotion : AJHP·2026

Same author

Educating health professionals in evidence-based practice in 2026.

BMJ evidence-based medicine·2026

Search research articles

Related Experiment Video

Updated: May 16, 2026

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

Published on: November 7, 2025

Prostate-specific antigen (PSA) test for prostate cancer screening.

Juan Va Franco¹, Eu Chang Hwang², Jae Hung Jung^3,4

¹Cochrane Evidence Synthesis Unit Germany/UK - Düsseldorf Subunit, Institute of General Practice, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

The Cochrane Database of Systematic Reviews

|May 14, 2026

Summary

Prostate cancer screening likely reduces cancer-specific deaths and may reduce overall mortality. However, evidence on harms and newer screening methods like PSA, kallikrein, and MRI remains limited.

More Related Videos

A Murine Orthotopic Bladder Tumor Model and Tumor Detection System

A Murine Orthotopic Bladder Tumor Model and Tumor Detection System

Published on: January 12, 2017

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

Related Experiment Videos

Last Updated: May 16, 2026

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

Published on: November 7, 2025

A Murine Orthotopic Bladder Tumor Model and Tumor Detection System

A Murine Orthotopic Bladder Tumor Model and Tumor Detection System

Published on: January 12, 2017

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

Area of Science:

Urology
Oncology
Preventive Medicine
Evidence-Based Medicine

Background:

Prostate cancer screening's efficacy and mortality reduction remain debated.
Previous reviews indicated no significant mortality benefit from screening.
New large trials and extended follow-up data necessitate an updated review.

Purpose of the Study:

To evaluate the impact of prostate cancer screening versus no screening on mortality and diagnosis.
To assess critical outcomes including prostate cancer-specific mortality, overall mortality, and adverse events.
To analyze important outcomes such as quality of life and stage-specific cancer diagnoses.

Main Methods:

Systematic review and meta-analysis of randomized controlled trials (RCTs).
Inclusion of six RCTs with 789,086 participants aged 45-80.
Data synthesis using random-effects models, assessing evidence certainty with GRADE.

Main Results:

Prostate-specific antigen (PSA) screening likely reduces prostate cancer-specific mortality (moderate-certainty evidence).
Screening may slightly reduce overall mortality (low-certainty evidence) but has little effect on adverse events.
Screening significantly increases prostate cancer diagnoses, including localized stages, but has less impact on advanced stages.

Conclusions:

Prostate cancer screening, particularly PSA-based, appears to reduce prostate cancer-specific mortality.
Evidence on overall mortality reduction is less certain, and harms require further investigation.
Emerging screening methods (kallikrein, MRI) show potential but lack sufficient mortality data.