Facilitators, barriers and intervention strategies for medication adherence in patients receiving thyroid hormone...

What is already known on this subject? The standard treatment for patients with hypothyroidism is THRT, which offers numerous advantages.Many original studies have explored the factors influencing medication adherence regarding THRT; however, reviews and systematic syntheses on this topic remain limited.Previous studies on THRT adherence have often lacked a systematic framework or theoretical integration; therefore, the extent to which they address barriers to and facilitators of adherence remains unclear.What does this study add? We employed a mixed-methods approach, integrating perspectives from key stakeholders (e.g., patients, healthcare providers) to explore factors influencing medication adherence in patients undergoing THRT.The top three significant barriers were inconvenient administration times, lack of disease knowledge and lack of medication knowledge. The top three facilitators were older age, regular follow-up and positive anticipated outcomes.The study highlights the interplay of individual, interpersonal, healthcare and socioeconomic factors, emphasizing that barriers and facilitators are context dependent and often interrelated. Implementing effective adherence strategies requires collaborative efforts across stakeholders to address these multifaceted challenges.