[Vasomics: an emerging omics discipline for deciphering vascular health and disease]

The vascular system serves as the central architecture of the human circulatory network, whose structural and functional integrity is vital for maintaining homeostasis and is closely associated with the development and progression of major diseases, including cardiovascular diseases, cerebrovascular diseases, hepatic disorders, ocular diseases, and renal conditions. Traditional single-dimensional research models present evident limitations in deciphering the complex vascular system. In this context, this article formally introduces the concept of "Vasomics". Vasomics is an emerging omics discipline that integrates clinical medicine, basic medicine, biology, computer science and artificial intelligence to systematically analyze the vascular system using multimodal and cross-scale approaches. This article elaborates on Vasomics from six key aspects: its background, core technologies and phenotyping, methodological framework, research progress, applications, and challenges and prospects. By enabling the integration of multi-scale vascular phenotypes from macroscopic to microscopic levels, Vasomics is poised to offer a new paradigm for deciphering vascular health and disease.