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Related Concept Videos

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

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Related Experiment Video

Updated: May 16, 2026

Vascular Organoid Generation from Human-Induced Pluripotent Stem Cells
04:41

Vascular Organoid Generation from Human-Induced Pluripotent Stem Cells

Published on: December 13, 2024

Automated stem cell-derived organoid platforms for disease modeling.

Xingrui Mou1, Nathan Dale1, Kiran Ramnarine1

  • 1JAX-NYSCF (The Jackson Laboratory for Stem Cell Research), New York, NY, USA.

Trends in Biotechnology
|May 14, 2026
PubMed
Summary
This summary is machine-generated.

Human organoids derived from stem cells offer better disease modeling than traditional methods. Combining these 3D organoids with automation promises scalable, reproducible research for drug development.

Keywords:
automation and high-throughput systemscomplex disease modelingiPSC-derived organoids

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Last Updated: May 16, 2026

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Generation of hiPSC-Derived Intestinal Organoids for Developmental and Disease Modelling Applications
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Generation of hiPSC-Derived Intestinal Organoids for Developmental and Disease Modelling Applications

Published on: March 8, 2024

Area of Science:

  • Biotechnology
  • Stem Cell Biology
  • Disease Modeling

Background:

  • Complex diseases result from intricate genetic, environmental, and lifestyle interactions, posing significant modeling challenges.
  • Traditional animal and 2D cell models lack scalability, reproducibility, and human relevance for studying complex diseases.
  • Current human organoid models, while promising, face limitations in protocol duration, variability, and labor intensity, hindering high-throughput applications.

Purpose of the Study:

  • To explore the potential of combining human-induced pluripotent stem cells (iPSCs)-derived organoids with automation for advanced disease modeling.
  • To address the limitations of current organoid technologies, including scalability, reproducibility, and labor intensity.
  • To highlight the transformative impact of automated organoid systems on drug discovery and development.

Main Methods:

  • Utilizing human-induced pluripotent stem cells (iPSCs) for differentiation into 3D organoids.
  • Implementing suspension bioreactors and multilineage differentiation techniques to enhance organoid yield and function.
  • Integrating automated high-throughput liquid handling systems for large-scale and reproducible organoid production.

Main Results:

  • Automation enables scalable and reproducible production of iPSC-derived organoids.
  • Advancements in bioreactor and differentiation techniques improve organoid yield and functionality.
  • Overcoming challenges in tissue maturity, vascularization, and consistency is crucial for robust organoid models.

Conclusions:

  • The integration of automation with iPSC-derived organoids represents a significant advancement in disease modeling.
  • Automated organoid platforms are poised to revolutionize drug development by enabling high-throughput, human-relevant screening.
  • This approach offers a pathway to more accurate and efficient preclinical research for complex human diseases.