Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Patch Clamp

Patch Clamp

Many fundamental cell functions such as muscle contraction and nerve transmission rely on the electrical signals produced by the movement of positively and negatively charged ions across the cell membrane. One competent method to record current flowing across the whole cell or single ion channel is the patch-clamp technique.
In this method, a glass micropipette containing electrolyte solution is tightly sealed against a small portion of the cell membrane. As a result, a patch of the cell...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Extended Cancer Spectrum in Adults With Telomere Biology Disorders: Insights From a 113-Patient Single-Center Cohort.

American journal of hematology·2026

Same author

Characteristics and outcomes of secondary hematological malignancies following autologous stem cell transplantation for multiple myeloma.

Blood cancer journal·2026

Same author

Limited Survival Benefit and High Healthcare Utilization With AML-Directed Therapy in Older Patients With TP53-Mutated Acute Myeloid Leukemia.

American journal of hematology·2026

Same author

Promoter TERT-Related Hematopoietic Somatic Mosaicism in Patients With Telomere Biology Disorders.

American journal of hematology·2026

Same author

Therapeutic Outcomes in VEXAS Syndrome: A Multicenter Comparative Cohort of Allogeneic Hematopoietic Stem Cell Transplantation and Hypomethylating Agents.

American journal of hematology·2026

Same author

Ontogeny and Natural History of Therapy-Related Clonal Hematopoiesis From a Multidisciplinary CHIP Clinic.

American journal of hematology·2026

Same journal

Adult acute lymphoblastic leukemia: incorporation of recent advances into current treatment strategies.

Blood cancer journal·2026

Same journal

Response profile and long-term outcomes in Cyclin D1-overexpressing multiple myeloma: insights from the CASSIOPEIA trial.

Blood cancer journal·2026

Same journal

Genomic loss of MLH1/PMS2 loci defines a mismatch repair deficient subgroup in monomorphic epitheliotropic intestinal T-cell lymphoma.

Blood cancer journal·2026

Same journal

Long-term clinical outcomes from the smart start trial: rituximab, lenalidomide and ibrutinib in patients with newly diagnosed large B-cell lymphoma.

Blood cancer journal·2026

Same journal

Expression profile of CASSIOPEIA patients refines prognostic value of MRD negativity in multiple myeloma.

Blood cancer journal·2026

Same journal

Zanubrutinib combined with R-CHOP in previously untreated diffuse large B-cell lymphoma with specific gene alteration: a phase II study.

Blood cancer journal·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 16, 2026

Reconstituting Cytoarchitecture and Function of Human Epithelial Tissues on an Open-Top Organ-Chip

Reconstituting Cytoarchitecture and Function of Human Epithelial Tissues on an Open-Top Organ-Chip

Published on: February 17, 2023

CHIP clinics: a practical overview of structure and function.

Shyam A Patel¹, Abhishek A Mangaonkar²

¹Department of Medicine, Division of Hematology/Oncology, UMass CHIP Clinic, UMass Chan Medical School, Worcester, MA, USA. shyam.patel@umassmed.edu.

Blood Cancer Journal

|May 14, 2026

Summary

This summary is machine-generated.

Clonal hematopoiesis of indeterminate potential (CHIP) clinics are emerging globally. This study proposes a working model for establishing effective CHIP clinics to advance translational science and patient care.

More Related Videos

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Published on: October 20, 2018

Culturing and Electrophysiology of Cells on NRCC Patch-clamp Chips

Culturing and Electrophysiology of Cells on NRCC Patch-clamp Chips

Published on: February 7, 2012

Related Experiment Videos

Last Updated: May 16, 2026

Reconstituting Cytoarchitecture and Function of Human Epithelial Tissues on an Open-Top Organ-Chip

Reconstituting Cytoarchitecture and Function of Human Epithelial Tissues on an Open-Top Organ-Chip

Published on: February 17, 2023

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Published on: October 20, 2018

Culturing and Electrophysiology of Cells on NRCC Patch-clamp Chips

Culturing and Electrophysiology of Cells on NRCC Patch-clamp Chips

Published on: February 7, 2012

Area of Science:

Hematology
Pre-malignant conditions
Translational science

Background:

Clonal hematopoiesis of indeterminate potential (CHIP) is a pre-malignant condition.
Existing CHIP clinics aim to standardize management.
Translational research is limited by nascent therapeutic concepts and follow-up data.

Purpose of the Study:

To explore the structure and function of current CHIP clinics.
To propose a working model for future CHIP clinics in academic and community settings.
To identify critical elements for operationalizing CHIP clinic workflows.

Main Methods:

Review of existing CHIP clinic structures and functions.
Development of a proposed working model for CHIP clinic operationalization.
Discussion of key components including patient identification, personnel recruitment, and workflow design.

Main Results:

CHIP clinics offer clinical utility in preventive hematology and risk assessment.
They facilitate clinical trial enrollment, research registries, and tissue biorepositories.
Multidisciplinary teams and community outreach are crucial for effective CHIP clinics.

Conclusions:

Establishing standardized CHIP clinics is vital for advancing translational science.
These clinics can improve patient outcomes through enhanced risk assessment and research opportunities.
Future multi-center collaboration holds promise for developing new CHIP therapeutics.