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Updated: May 16, 2026

Creation of Abdominal Adhesions in Mice

Creation of Abdominal Adhesions in Mice

Published on: August 27, 2016

Rats develop more robust and persistent peritoneal adhesion phenotypes than mice: a multimodal comparative study.

Junliang Li^1,2,3, Zhenjun Pu⁴, Hongyu Nian⁴

¹Department of General Surgery, Gansu Provincial Hospital, 204 Donggang West Road, Lanzhou, 730030, Gansu, China.

Scientific Reports

|May 14, 2026

Summary

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This summary is machine-generated.

Rats develop more severe peritoneal adhesions than mice, showing greater collagen and profibrotic protein deposition. The rat model offers a more clinically relevant platform for studying peritoneal adhesions.

Area of Science:

Biomedical research
Surgical pathology
Translational science

Background:

Peritoneal adhesions (PAs) are a significant postsurgical complication.
Animal models are crucial for understanding PA pathogenesis and developing treatments.
Existing models may not fully recapitulate human PA characteristics.

Purpose of the Study:

To compare the development and characteristics of peritoneal adhesions in rat and mouse models.
To evaluate the suitability of rat and mouse models for clinical phenotype studies and translational research.

Main Methods:

Established postoperative PA models using cecum-abdominal wall ischemic injury suture in Sprague-Dawley rats and BALB/c mice.
Systematically evaluated adhesion progression using micro-computed tomography (CT), macroscopic scoring (DASI), histopathology, immunohistochemistry, and scanning electron microscopy (SEM).

Keywords:

Animal model Mouse Peritoneal adhesion Peritoneal ultrastructure Rat

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Compared peritoneal morphology between humans and rodents via SEM.

Main Results:

Rats exhibited significantly more severe and persistent adhesions than mice, with denser CT shadows and higher DASI scores.
Histological analysis revealed greater collagen deposition and higher TGF-β1 and fibronectin expression in rats.
SEM showed the rat peritoneum possesses more abundant microvilli and a regular texture, resembling the human peritoneum more closely than the mouse peritoneum.

Conclusions:

The rat model demonstrates more robust and persistent peritoneal adhesion features compared to the mouse model.
The rat model is a more suitable platform for clinical phenotype studies and translational evaluation of peritoneal adhesions.
Morphological similarities between the rat peritoneum and human peritoneum provide a valuable reference for interspecies differences in PA development.