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Updated: May 16, 2026
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Magnetic resonance spectroscopy during migraine attacks: A systematic review
Delia-Ioana Radutiu1, Edina Szabo2,3, Rune Häckert Christensen1,4,5
1Department of Neurology, Center for Discoveries in Migraine and Danish Headache Center, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Migraine attacks involve altered brain energy metabolism, especially in visual and brainstem areas. Further research is needed to confirm these neurochemical changes using magnetic resonance spectroscopy (MRS).
Area of Science:
- Neuroscience
- Biochemistry
- Medical Imaging
Background:
- The neurobiological underpinnings of migraine are not fully understood.
- Magnetic resonance spectroscopy (MRS) offers non-invasive insights into brain neurochemistry and metabolism.
- This review critically assesses MRS findings during migraine attacks.
Conclusions:
- Migraine attacks are linked to altered cerebral energy metabolism, particularly in visual cortex and brainstem regions.
- Significant variability in study methodologies hinders direct comparisons and confirms reproducibility.
- Well-designed longitudinal MRS studies are required to establish reliable, attack-related metabolic signatures.
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