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Assessment of Kidney Function in Mouse Models of Glomerular Disease
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Published on: June 30, 2018

Appraising the causal relationship between kidney function and hearing performance: a two-sample Mendelian

Weiling Huang1, Zhao Li2, Yue Zhang3

  • 1School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Renal Failure
|May 14, 2026
PubMed
Summary
This summary is machine-generated.

This study found no genetic evidence that kidney function traits causally impact hearing ability, measured by speech reception threshold. The observed association between chronic kidney disease and hearing impairment may stem from other shared factors.

Keywords:
Mendelian randomizationcausal inferencechronic kidney diseaseestimated glomerular filtration rategenome-wide association studysensorineural hearing loss

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Area of Science:

  • Genetics
  • Nephrology
  • Audiology

Background:

  • Epidemiological studies suggest a link between chronic kidney disease (CKD) and hearing impairment.
  • The causal nature of this association remains unclear, necessitating further investigation.

Purpose of the Study:

  • To investigate the potential causal relationship between genetically predicted kidney function and speech reception threshold (SRT).
  • To examine this relationship bidirectionally using Mendelian randomization.

Main Methods:

  • A bidirectional two-sample Mendelian randomization study was performed.
  • Genetic instruments for estimated glomerular filtration rate (eGFR), CKD, and blood urea nitrogen (BUN) were sourced from large genome-wide association studies.
  • Speech reception threshold data were obtained from the UK Biobank; inverse variance weighted (IVW) and other MR methods were employed.

Main Results:

  • No robust causal associations were found between genetically predicted kidney function traits (eGFR, CKD, BUN) and SRT in either ear.
  • While some analyses showed nominal significance, results were inconsistent across methods and did not meet criteria for robust causal inference.
  • Reverse Mendelian randomization analyses also yielded non-significant results, and sensitivity analyses ruled out significant pleiotropy.

Conclusions:

  • This study provides no strong genetic evidence for a causal link between kidney function and hearing function (SRT).
  • The observed epidemiological association might be explained by shared systemic, developmental, or environmental factors rather than a direct causal effect.