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Multimodal MRI Reveals Brain Structural Differences and Executive Dysfunction in Early Methamphetamine Abstinence.

Ben Bristow^1,2, Maryam Tayebi^1,3, Paul Condron¹

¹Mātai Medical Research Institute, Gisborne, New Zealand.

Brain and Behavior

|May 15, 2026

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This summary is machine-generated.

Methamphetamine use disorder causes significant cognitive deficits and structural brain changes, particularly in grey matter. Early abstinence reveals lasting cortical alterations, highlighting vulnerability to methamphetamine-induced damage.

Area of Science:

Neuroscience
Addiction Research
Cognitive Psychology

Background:

Methamphetamine use disorder (MUD) significantly impacts brain structure and cognitive functions.
Understanding neurobiological changes during early abstinence is vital for effective rehabilitation.

Purpose of the Study:

To investigate structural brain alterations in early abstinent MUD individuals.
To assess cognitive functions in MUD participants compared to healthy controls.

Main Methods:

Compared 13 early abstinent MUD participants with 14 healthy controls.
Utilized 3T MRI for T1-weighted and myelin-sensitive imaging.
Administered the Tower of London (TOL) test for executive function assessment.

Main Results:

Keywords:

MRI brain cognitive function early abstinence methamphetamine

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MUD participants showed impaired executive function, evidenced by longer task completion times and more attempts.
Significant cortical thinning and reduced grey matter volume were observed in specific brain regions of MUD participants.
Duration of methamphetamine use correlated negatively with cortical volume in multiple brain areas.

Conclusions:

Methamphetamine use is associated with diminished executive function and observable cortical changes.
Grey matter appears more susceptible to methamphetamine-induced damage than white matter, as indicated by myelin measures.
Findings underscore the neurobiological impact of MUD and inform targeted interventions.