Related Experiment Video
Updated: May 16, 2026
06:07
Evaluating Cell Death Using Cell-Free Supernatant of Probiotics in Three-Dimensional Spheroid Cultures of Colorectal Cancer Cells
Published on: June 13, 2020
Probiotics Cancer Interaction, Prevention, and Therapy
Mostafa Saebi1,2, Amir Hossein Barjasteh1,2, Mahmoud Mahmoudi1,3
1Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Immunity, Inflammation and Disease
|May 15, 2026
Summary
Probiotics can improve gut health and immune function, potentially aiding in cancer prevention and treatment. This review highlights their role in mitigating side effects from cancer therapies and enhancing patient outcomes.
Area of Science:
- Oncology
- Microbiology
- Immunology
Background:
- Cancer is a leading global cause of death, influenced by genetics and lifestyle factors including gut microbiota.
- Gut dysbiosis (microbial imbalance) is linked to cancer development.
- Probiotics show potential for improving gut health and immune function.
Purpose of the Study:
- To review the role of probiotics in cancer prevention and treatment.
- To explore mechanisms by which probiotics influence cancer.
- To underscore the need for integrating probiotics into cancer therapy.
Main Methods:
- Comprehensive literature review.
- Analysis of existing research on probiotics and cancer.
- Synthesis of findings on probiotic mechanisms and therapeutic potential.
Main Results:
- Probiotics modulate gut bacteria, alter metabolic functions, and degrade carcinogens.
- They enhance immune checkpoint inhibitor efficacy and reduce inflammation.
- Probiotics can inhibit the production of cancer-causing compounds.
Conclusions:
- Probiotics offer a promising avenue for cancer prevention and treatment.
- Integrating probiotics may mitigate adverse effects of conventional cancer therapies.
- Further research is needed to optimize probiotic use for improved patient outcomes and cancer prevention.
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