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RBM45 Preferential Binding to m6A: Simulations Suggest Synergy of RRM3 and Other Domains

Raeyeon Park1, Lydia M Contreras2, Phanourios Tamamis1,3

  • 1Artie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, Texas 77843, United States.

The Journal of Physical Chemistry. B
|May 15, 2026
PubMed
Summary

RNA-binding motif protein 45 (RBM45) preferentially binds N6-methyladenosine (m6A) RNA motifs. Molecular dynamics simulations reveal synergistic interactions between RBM45 domains for this m6A preference, offering mechanistic insights.

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