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Association Between Preoperative Systemic Inflammatory Indices and Visual Outcomes After Cataract Surgery.

Gaofang Xu^1,2, Ying Zhang¹, Yuan Yuan^1,2

¹Department of Ophthalmology, The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), 563000 Zunyi, Guizhou, China.

Annali Italiani Di Chirurgia

|May 15, 2026

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Preoperative inflammatory markers like SII, SIRI, and AISI are linked to poor visual outcomes after cataract surgery. These indices may help stratify surgical risk.

Area of Science:

Ophthalmology
Immunology
Biostatistics

Background:

Cataract surgery is a common procedure with potential for visual complications.
Systemic inflammation may influence surgical outcomes.
Preoperative inflammatory indices are not well-established predictors of cataract surgery results.

Purpose of the Study:

To evaluate the association between preoperative systemic inflammatory indices and poor visual outcomes after cataract surgery.
Investigate the predictive value of systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI) for visual outcomes.
Determine if these indices can aid in perioperative risk stratification.

Main Methods:

Retrospective study of 240 patients undergoing cataract surgery.

Keywords:

cataract surgery postoperative visual outcomes retrospective study systemic inflammatory indices

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Calculation of SII, SIRI, and AISI from preoperative complete blood counts.

Analysis of poor visual outcomes at 4 weeks postoperatively using multivariable logistic regression and restricted cubic spline models.

Main Results:

The systemic immune-inflammation index (SII) showed a nonlinear association with poor visual outcomes.
Higher SII tertiles and specific SII ranges were linked to increased odds of poor vision.
Adjusted analyses revealed significant associations between SIRI and AISI and worse short-term visual outcomes.
SII and AISI independently predicted poor postoperative vision.

Conclusions:

Preoperative SII, SIRI, and AISI are significantly associated with worse short-term visual outcomes post-cataract surgery.
These inflammatory indices, especially SII and AISI, may offer valuable clinical insights for perioperative risk assessment.
Further prospective studies are needed to validate these findings and explore anti-inflammatory interventions.