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Target-based Antidiabetic Indole Derivatives and Insights into Structure-activity Relationships: A Mechanistic Update

Ankita Wal1, Pranay Wal1, Akanksha Gupta2

  • 1PSIT-Pranveer Singh Institute of Technology (Pharmacy), Kanpur, India.

Current Drug Targets
|May 15, 2026
PubMed
Abstract

Keywords:
AIassisted drug designAMPK activationDPP-4 inhibitorsIndole derivativesantidiabetic agentsclinical trialsenzyme inhibitiongreen chemistry synthesis.insulin sensitizationnanoparticle formulationpersonalized medicinestructure activity relationship (SAR)targeted drug deliverytype 2 diabetes mellitus (T2DM)β-cell protection

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