Research Progress of Extracellular Matrix Hardness in Fibrotic Diseases

Extracellular matrix is a 3D reticular molecular structure that maintains the structures and functions of cells and provides biomechanical support for cell proliferation and differentiation.The increase in extracellular matrix hardness can destroy the ecological structures and biological functions of normal organs and affect the signal transduction of normal tissue and cells,being a key driver of organ fibrosis.Therefore,reducing the extracellular matrix hardness by inhibiting key signaling pathways and activating fibroblasts can reverse organ fibrosis and promote the steady development of extracellular matrix.This paper expounds the key role of extracellular matrix hardness in fibrosis diseases,providing key therapeutic targets and clinical research directions for ameliorating and reversing organ fibrosis.