Arbutin as a Therapeutic Agent: Protein Modulating Potential and Pharmacology Perspective

Arbutin, a glycosylated hydroquinone derivative, has garnered considerable attention for its pharmacological versatility. Initially popularized for its depigmenting effects in dermatology, arbutin has since been explored for a broad spectrum of biological activities, including antioxidant, anti-inflammatory, antimicrobial, anticancer, and neuroprotective properties. This review consolidates recent findings on arbutin's pharmacodynamics, mechanisms of action, and potential therapeutic applications, emphasizing its relevance in modern pharmacological research. This manuscript describes the biochemical pathways of arbutin, as well as its absorption, distribution, metabolism, and excretion. Furthermore, the toxicity concerns associated with various challenges in clinical translation warrant further screening. Researchers must focus on developing novel dosage forms and innovative strategies to enhance the therapeutic outcomes of arbutin in modern pharmacological research. Arbutin is a promising natural therapeutic drug with several biomedical uses, but further studies in molecular pharmacology, nanotechnology, and clinical evaluation are needed to optimise its therapeutic potential.