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Related Experiment Video

Updated: May 16, 2026

Generation and Downstream Analysis of Single-Cell and Single-Nuclei Transcriptomes in Brain Organoids
05:45

Generation and Downstream Analysis of Single-Cell and Single-Nuclei Transcriptomes in Brain Organoids

Published on: March 29, 2024

Opportunities and challenges in studying non-coding RNAs using neural organoid models.

Po-Sung Chiang1,2, Meng-Han Tsai3,4,5, Pei-Shan Hou1,6,7

  • 1Institute of Anatomy and Cell Biology, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Frontiers in Molecular Neuroscience
|May 15, 2026
PubMed
Summary

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Three-dimensional neural organoids offer a superior model for studying non-coding RNAs (ncRNAs) in brain development and disease. This advanced platform overcomes limitations of 2D cultures for investigating complex ncRNA functions.

Area of Science:

  • Neuroscience and Genomics
  • Investigating the role of non-coding RNAs (ncRNAs) in human brain development and neurological disorders.

Background:

  • Whole-genome sequencing reveals non-coding RNAs (ncRNAs) as key biological regulators.
  • Studying neural ncRNAs in vitro is difficult due to complex expression and regulatory networks poorly represented in 2D cultures.
  • Three-dimensional (3D) neural organoids provide a high-fidelity platform for advanced biological research.

Purpose of the Study:

  • To review the current state of ncRNA research using neural organoid systems.
  • To highlight the utility of neural organoids in modeling neurodevelopment and simulating diseases.
  • To discuss the potential of these 3D models for decoding the non-coding genome and for preclinical applications.

Main Methods:

  • Review of current literature on ncRNA research in neural organoid systems.
Keywords:
circular RNA (circRNA)long non-coding (lnc) RNAmicroRNAneural organoidnon-coding RNA (ncRNA)

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Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases
09:36

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases

Published on: June 28, 2019

Related Experiment Videos

Last Updated: May 16, 2026

Generation and Downstream Analysis of Single-Cell and Single-Nuclei Transcriptomes in Brain Organoids
05:45

Generation and Downstream Analysis of Single-Cell and Single-Nuclei Transcriptomes in Brain Organoids

Published on: March 29, 2024

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases
09:36

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases

Published on: June 28, 2019

  • Analysis of findings related to microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and small nuclear RNAs (snRNAs).
  • Examination of studies focusing on neurodevelopmental modeling and disease simulation using 3D neural organoids.

    • Main Results:

    • Neural organoids effectively model complex ncRNA functions and regulatory networks relevant to brain development.
    • These 3D systems facilitate the study of ncRNAs in the context of neurological diseases.
    • Advancements in neural organoids provide insights into the non-coding genome's role in human brain function and pathology.

    Conclusions:

    • Neural organoids are essential for understanding the non-coding genome's contribution to brain development and disease.
    • These models bridge the gap between complex ncRNA biology and functional outcomes in the human brain.
    • The use of neural organoids holds significant potential for preclinical research and therapeutic development in neuroscience.