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Nodular B-Cell Cutaneous Lymphoid Infiltrate With Limited Tissue for Molecular Evaluation: A Case Highlighting
Sri Naidnur1, Coral Martes-Villalobos2, Sonia A Neave3
1Dermatology, Oasis Dermatology Group, McAllen, USA.
Cureus
|May 15, 2026
Summary
Cutaneous lymphoid infiltrates pose diagnostic challenges, mimicking lymphoma. This case highlights how insufficient tissue for molecular testing can lead to diagnostic uncertainty and varied management approaches for skin lesions.
Area of Science:
- Dermatology
- Pathology
- Oncology
Background:
- Cutaneous lymphoid infiltrates are challenging to diagnose, often mimicking lymphoma.
- Molecular testing (gene rearrangement studies) can aid in assessing clonality but isn't always feasible.
- Diagnostic uncertainty can arise from limited tissue samples for analysis.