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Symptom reduction and safety profile of uterine artery embolization for symptomatic fibroids
Jaroslaw Krzyzanowski1, Tomasz Paszkowski2, Piotr Szkodziak2
13rd Chair and Department of Gynecology, Medical University of Lublin, Poland. krzyzanowski.jaroslaw@tlen.pl.
Objectives:
To assess long-term efficacy and safety of uterine artery embolization for symptomatic uterine fibroids.
Material And Methods:
This retrospective cohort study included women undergoing uterine artery embolization for symptomatic fibroids from 2012 to 2023. A validated questionnaire assessed symptoms (e.g., heavy menstrual bleeding, pelvic pain) pre- and post- uterine artery embolization. Data on fibroid characteristics, follow-up duration, menopause status, and complications were collected. Patients were stratified into follow-up terciles. Statistical analyses included Wilcoxon signed-rank tests, linear regression with menopause adjustment, and Spearman correlations tests (p < 0.05).
Results:
Uterine artery embolization significantly reduced symptoms, particularly bleeding-related complaints, with sustained efficacy across short-, mid-, and long-term follow-up, even after menopause adjustment. Menopause enhanced symptom relief. No correlations were found between symptom reduction and age, fibroid size, or prior treatment. Complications, mostly minor, occurred in a notable proportion, with rare major events. A small subset achieved successful pregnancies post-embolization.
Conclusions:
Uterine artery embolization is an effective, minimally invasive treatment for fibroid-related symptoms, with sustained benefits over time; menopause significantly predicts greater symptom improvement.
