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Updated: May 16, 2026

Intra-cardiac Side-Firing Light Catheter for Monitoring Cellular Metabolism using Transmural Absorbance Spectroscopy of Perfused Mammalian Hearts
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Myocardium-Targeted Near Infrared-IIb Emitting Atomically Dispersed Catalysts for ROS Scavenging in Acute Myocardial

Shuli Bi1,2, Jing Wang2, Xue-Hui Shi3

  • 1School of Medicine, Nankai University, Tianjin, P. R. China.

Small (Weinheim an Der Bergstrasse, Germany)
|May 15, 2026
PubMed
Summary
This summary is machine-generated.

Researchers developed targeted nanoparticles for acute myocardial infarction (AMI) treatment. These manganese-doped quantum dots scavenge reactive oxygen species (ROS) and reduce inflammation, improving cardiac function with real-time imaging.

Keywords:
NIR‐IIb imagingacute myocardial infarctionmanganese‐doped Ag2Te QDsmyocardial targetingreactive oxygen species scavenging

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Published on: July 25, 2025

Area of Science:

  • Biomedical Engineering
  • Nanomedicine
  • Cardiovascular Research

Background:

  • Acute myocardial infarction (AMI) causes cardiomyocyte death via oxidative stress and inflammation.
  • Reperfusion injury is exacerbated by reactive oxygen species (ROS) and inflammation.
  • Current anti-inflammatories pose risks of systemic immunosuppression.

Purpose of the Study:

  • To develop a novel therapeutic platform for AMI.
  • To achieve targeted myocardial delivery, ROS scavenging, and real-time imaging.
  • To evaluate the efficacy and safety of manganese-doped Ag2Te quantum dots (Mn: Ag2Te QDs) modified with tannic acid (TA).

Main Methods:

  • Synthesis of Mn: Ag2Te QDs surface-modified with TA.
  • Evaluation of ROS scavenging and anti-inflammatory properties in vitro and in vivo.
  • Assessment of cardiac targeting, biodistribution via NIR-IIb imaging, and cardiac function recovery.
  • Analysis of biocompatibility and safety profiles.

Main Results:

  • Mn: Ag2Te QDs demonstrated potent enzyme-mimetic antioxidant activity, efficiently scavenging ROS.
  • TA modification ensured selective accumulation in infarcted myocardium.
  • NIR-IIb imaging enabled noninvasive monitoring of drug distribution.
  • Studies showed reduced inflammation, improved cardiac function, and favorable safety.

Conclusions:

  • The integrated platform combines myocardial targeting, ROS scavenging, and NIR-IIb imaging for AMI precision treatment.
  • This approach offers a promising strategy to mitigate ischemia-reperfusion injury.
  • The developed Mn: Ag2Te QDs show potential for advanced cardiovascular therapies.