Related Experiment Videos
Pharmacological activity, molecular mechanisms and therapeutic potential of erianin (Review)
Chengyi Ming1, Ni Zhu1, You Yu1
1Hubei Key Laboratory of Environmental Risks and Related Diseases Precision Control, School of Basic Medical Sciences, Xianning Medical College, Hubei University of Science and Technology, Xianning, Hubei 437100, P.R. China.
Abstract:
As a natural active ingredient extracted from Dendrobium chrysotoxum, erianin shows multi‑target regulatory characteristics. The present review aimed to summarize the physiological effects, molecular mechanisms and therapeutic potential of erianin. Erianin has application bottlenecks such as poor water solubility and low bioavailability. The druggability of erianin could be effectively improved through structural modification, development of new drug delivery systems and combined drug use strategies. Although the in vitro synthesis process of erianin has been optimized for high yield and reproducibility, the in vivo toxicity and targeting need to be further optimized. The current review provides novel ideas for the systematic development of natural products, and guidance for promoting the clinical transformation of erianin.
Related Concept Videos
01:16Adrenergic Agonists: Chemistry and Structure-Activity Relationship
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of the aromatic...
01:30Adrenergic Agonists: Therapeutic Uses
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and anaphylaxis:...
01:28Adrenergic Agonists: Mixed-Action Agents
Ephedrine and pseudoephedrine lack a catecholamine group, making them less susceptible to degradation by metabolic enzymes. They have increased oral bioavailability and lipophilicity, resulting in a longer duration of action. Their response is reduced by...
01:18Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme (ECE). Of...
01:18Adrenergic Agonists: Therapeutic Classification
Vasopressor or pressor agents: They increase blood pressure and function as cardiac stimulants. Examples include endogenous catecholamines (norepinephrine and dopamine) and synthetic agents (phenylephrine).
Bronchodilators: β2-agonists can relax bronchial muscles and widen airways. They are commonly used for treating obstructive pulmonary...
01:28Structure-Activity Relationships and Drug Design
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence its...