Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cellular Adaptation IV: Dysplasia and Metaplasia01:24

Cellular Adaptation IV: Dysplasia and Metaplasia

DysplasiaDysplasia refers to abnormal changes in the size, shape, and organization of mature cells, characterized by pleomorphism, nuclear abnormalities, and increased mitotic activity. It commonly affects epithelial tissues, including the cervix, gastrointestinal tract, respiratory mucosa, and endometrium. Although it may occur alongside hyperplasia, dysplasia is not a true adaptive response but a preneoplastic change with potential to progress to cancer.When confined above the basement...
Classification of Epithelial Tissues: Overview01:22

Classification of Epithelial Tissues: Overview

Epithelial tissues are classified according to the shape of the cells and the number of cell layers formed. Cell shapes can be squamous (flattened and thin), cuboidal (square-like, as wide as it is tall), or columnar (rectangular, taller than it is wide). Additionally, the nucleus shape helps identify the type of epithelial cells. Squamous cells have flattened disc-shaped nuclei, cuboidal cells have spherical nuclei, and columnar cells have elongated nuclei.
Based on the number of cell layers,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Distinct molecular subgroups in pediatric and young-onset meningiomas require age-adapted risk stratification.

Nature communications·2026
Same author

Triage Performance of FAM19A4/miR124-2 Methylation: 18-Month Follow-Up Results From a Prospective Observational Study Within the Dutch Primary HPV-Based Cervical Screening Program.

International journal of cancer·2026
Same author

Activity and Physiological Stress Within 90 Days After Minimally Invasive and Open Pancreatoduodenectomy: A Predefined Analysis of the DIPLOMA-2 Randomized Clinical Trial.

JAMA surgery·2026
Same author

A Comparison of Methods for Modeling Multistate Cancer Progression Using Screening Data with Censoring after Intervention.

Medical decision making : an international journal of the Society for Medical Decision Making·2026
Same author

Long-term outcomes of surgical menopause after risk-reducing salpingo-oophorectomy: results of the HARMOny study.

Maturitas·2026
Same author

Cost-effectiveness of risk-stratified screening for cervical cancer in cohorts vaccinated against human papillomavirus with moderate vaccination coverage.

International journal of cancer·2026

Related Experiment Video

Updated: May 17, 2026

Establishment and Evaluation of a Risk Prediction Model for Pathological Escalation of Gastric Low-Grade Intraepithelial Neoplasia
03:05

Establishment and Evaluation of a Risk Prediction Model for Pathological Escalation of Gastric Low-Grade Intraepithelial Neoplasia

Published on: February 16, 2024

Recurrence in High-grade Vulvar Intraepithelial Neoplasia: A Comprehensive Cohort Analysis.

Dominique C de Vries1,2, Nikki B Thuijs1,2, Féline O Voss1,2

  • 1Department of Pathology, Amsterdam UMC.

Journal of Lower Genital Tract Disease
|May 15, 2026
PubMed
Summary

High-grade vulvar intraepithelial neoplasia (VIN) frequently recurs, especially HPV-independent VIN (HPVi-VIN). Recurrent cases, particularly HSIL, show increased cancer risk, highlighting the need for vigilant follow-up in VIN patients.

Keywords:
HPV-independent vulvar intraepithelial neoplasiabiomarkersdifferentiated VINhigh grade squamous intraepithelial lesionrecurrencerisk factorssurgical procedurestumor suppressor protein p53vulvar cancervulvar intraepithelial neoplasia

Related Experiment Videos

Last Updated: May 17, 2026

Establishment and Evaluation of a Risk Prediction Model for Pathological Escalation of Gastric Low-Grade Intraepithelial Neoplasia
03:05

Establishment and Evaluation of a Risk Prediction Model for Pathological Escalation of Gastric Low-Grade Intraepithelial Neoplasia

Published on: February 16, 2024

Area of Science:

  • Gynecologic Oncology
  • Dermatology
  • Oncology

Background:

  • High-grade vulvar intraepithelial neoplasia (VIN) is a precursor to vulvar squamous cell carcinoma (VSCC).
  • VIN is classified as human papillomavirus (HPV)-associated high-grade squamous intraepithelial lesion (HSIL) or HPV-independent VIN (HPVi-VIN).

Purpose of the Study:

  • To comprehensively characterize recurrence patterns in a large cohort of VIN patients.
  • To evaluate recurrence risk, number of recurrences, and associated procedures.
  • To identify risk factors for recurrence and cancer development in VIN patients.

Main Methods:

  • Retrospective analysis of 578 HSIL and 46 HPVi-VIN patients.
  • Assessment of recurrence risk, recurrence frequency, and surgical procedures.
  • Kaplan-Meier and Cox regression analyses for recurrence and cancer risk stratification.

Main Results:

  • Recurrence rates were 50% for HSIL and 63% for HPVi-VIN over median follow-up periods of 15 and 5.5 years, respectively.
  • Cancer was detected at first recurrence in 8.0% of HSIL and 45% of HPVi-VIN patients.
  • Recurrent HSIL demonstrated escalating cancer risk with subsequent recurrences, and no independent risk factors for HSIL recurrence were identified.

Conclusions:

  • Both HSIL and HPVi-VIN patients face significant risks of recurrence.
  • HPVi-VIN and recurrent HSIL are associated with a higher risk of developing cancer.
  • Long-term surveillance is crucial for managing VIN patients due to high recurrence and potential cancer progression.