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Related Experiment Videos

Prognostic Factors Associated With Mortality Among Patients With Necrotizing Soft-Tissue Infection: A Systematic

Natalia Kruger1, Kevin Durr1,2, Shannon M Fernando3,4

  • 1Department of Emergency Medicine, University of Ottawa, Ottawa, ON, Canada.

Critical Care Medicine
|May 15, 2026
PubMed
Summary

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This summary is machine-generated.

Necrotizing soft-tissue infections (NSTIs) are serious conditions. Older age, comorbidities like kidney disease, and factors like shock significantly increase mortality risk in NSTI patients.

Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Prognostic Research

Background:

  • Necrotizing soft-tissue infections (NSTIs) are life-threatening conditions requiring prompt management.
  • Effective treatment necessitates accurate prognostication based on patient and disease factors.

Purpose of the Study:

  • To systematically review and synthesize evidence on prognostic factors associated with mortality in adult patients diagnosed with NSTI.
  • To identify key patient and disease characteristics that predict short-term mortality in NSTI.

Main Methods:

  • A comprehensive literature search was conducted across Medline, Embase, and Cochrane Central Register of Controlled Trials up to September 29, 2025.
  • Included studies focused on adult NSTI patients, utilizing adjusted models for prognostic factor analysis.
Keywords:
Fournier gangrenemeta-analysismortalitynecrotizing soft-tissue infectionsystematic review

Related Experiment Videos

  • Meta-analysis using random-effects models and assessment of evidence certainty were performed.

    • Main Results:

    • The review encompassed 41 observational cohort studies with 168,261 patients.
    • Patient factors associated with increased mortality (moderate/high certainty) included older age, chronic liver/kidney disease, high comorbidity index, and immunosuppression.
    • Disease factors linked to higher mortality included hypotension, bacteremia, acute kidney injury, coagulopathy, thrombocytopenia, and shock.

    Conclusions:

    • Multiple patient and disease factors are significantly associated with mortality in NSTI.
    • These identified factors should guide clinical decision-making regarding treatment escalation and patient/family counseling.