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Related Concept Videos

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Related Experiment Video

Updated: May 17, 2026

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
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Published on: July 16, 2014

Sensory Function Improves With Subthalamic Nucleus Stimulation in Parkinson's: A Network Analysis.

Fiona E Permezel1, Jane E Alty2, Ian H Harding3

  • 1Department of Neuroscience, Monash University, Melbourne, Australia; Department of Neurology, Mayo Clinic, Rochester, MN, USA.

Neuromodulation : Journal of the International Neuromodulation Society
|May 15, 2026
PubMed
Summary

Deep brain stimulation for Parkinson disease (PD) can improve sensory decision-making by targeting the subthalamic nucleus and enhancing prefrontal cortex connectivity. This approach may help resolve sensory conflicts, improving quality of life for PD patients.

Keywords:
Brain networksParkinson diseasedeep brain stimulationsensory functionsubthalamic nucleus

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Published on: June 26, 2013

Area of Science:

  • Neuroscience
  • Neurology
  • Neurosurgery

Background:

  • Sensory dysfunction is a common symptom in Parkinson disease (PD), impacting motor function and quality of life.
  • Subthalamic nucleus deep brain stimulation (DBS) is effective for motor symptoms but also influences sensory processing.
  • Identifying specific stimulation targets and brain networks is crucial for optimizing sensory outcomes in PD patients undergoing DBS.

Purpose of the Study:

  • To identify specific stimulation sites within the subthalamic nucleus.
  • To determine the structural brain networks associated with improvements in sensory decision-making following DBS.
  • To explore the relationship between stimulation parameters and sensory illusion measures in PD.

Main Methods:

  • Retrospective analysis of data from 21 PD patients treated with subthalamic nucleus DBS.
  • Assessment of sensory decision-making using the rubber hand illusion, measuring proprioceptive drift, hand stroking illusion, and hand ownership illusion.
  • Computational modeling to identify stimulation "sweetspots" and connectome analysis to map associated brain networks, validated by permutation testing and region-of-interest analysis.

Main Results:

  • Normalization of proprioceptive drift was linked to stimulation of the left associative-limbic subthalamic nucleus and bilateral prefrontal cortex (PFC) connectivity.
  • Improvement in the stroking illusion correlated with contralateral motor and prefrontal network connectivity.
  • Region-of-interest analysis revealed that proprioceptive drift improvement involved bilateral executive and limbic networks, while stroking illusion improvement engaged contralateral executive, limbic, and somatomotor networks.

Conclusions:

  • Stimulation of the associative-limbic subthalamic nucleus and its connectivity with the PFC are key to enhancing sensory decision-making in Parkinson disease.
  • These findings suggest that DBS may modulate sensory decisional conflict resolution networks.
  • Further research into these relationships could facilitate individualized, symptom-based DBS therapies for PD.