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Updated: May 17, 2026

Improving IV Insulin Administration in a Community Hospital
Published on: June 11, 2012
Development of a protocol on safe practices for insulin preparation and administration
Tatiana Rebouças Moreira1, Rhanna Emanuela Fontenele Lima de Carvalho1, Consuelo Helena Aires de Freitas1
1Universidade Estadual do Ceará. Fortaleza, Ceará, Brazil.
A new protocol for safe insulin preparation and administration was developed and validated. This high-quality tool significantly improved healthcare professionals' knowledge of safe insulin practices.
Area of Science:
- Healthcare Quality Improvement
- Medication Safety Protocols
- Clinical Practice Guidelines
Background:
- Insulin preparation and administration errors pose significant risks in healthcare settings.
- Standardized protocols are essential for ensuring patient safety during insulin therapy.
- Existing protocols may require validation for optimal effectiveness and adherence.
Purpose of the Study:
- To develop and validate a comprehensive protocol for the safe preparation and administration of insulin.
- To assess the quality, validity, and reproducibility of the developed insulin protocol.
- To evaluate the impact of training based on the protocol on healthcare professionals' knowledge.
Main Methods:
- A two-phase methodological study involving expert review (AGREE II) and healthcare professional training.
- Protocol development and validation by 46 experts, followed by training of 40 professionals in Brazil.
- Statistical analysis included Content Validity Index, Cronbach's alpha, McDonald's omega, and pre/post-test knowledge assessment.
Main Results:
- The protocol demonstrated high quality (95.7% overall score) and content validity (97.83-100%), with excellent reproducibility (alpha=0.94, omega=0.95).
- All six AGREE II domains scored above 90.0%, indicating robust methodological and content aspects.
- Post-training knowledge significantly increased from 32% to 70% among healthcare professionals.
Conclusions:
- The validated insulin protocol is a high-quality, reliable tool for enhancing safe medication practices.
- Implementation of this protocol effectively improves healthcare professionals' understanding and application of safe insulin procedures.
- This validated protocol represents a significant advancement in patient safety technology for insulin management.
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