Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

π-π Stacking Enhanced Generation of Reactive Species in Donor-Acceptor Heterojunctions for High-Efficiency Photocatalytic Degradation of Endocrine-Disrupting Compounds under Solar Light.

ACS applied materials & interfaces·2026
Same author

Tracing the stemness and malignant transition in a heritable colorectal cancer Lynch Syndrome by single-cell RNA-seq analysis.

Frontiers in immunology·2026
Same author

Increased Cortical Thickness Combined With Altered Structural Covariance Networks in Functional Anorectal Pain.

Neurogastroenterology and motility·2026
Same author

Long non-coding RNA MIAT functions as a ceRNA to protect uveal melanoma from oxidative stress by sponging miR-4306 and upregulating CXCR4.

Experimental eye research·2026
Same author

Transcriptomic and metabolomic insights into the combined toxicity of acute glyphosate and copper exposure in water flea (Daphnia magna).

Environmental research·2026
Same author

Head-to-head comparison of fecal occult blood tests for colorectal neoplasia detection in Chinese outpatients: a multicenter diagnostic trial.

Scientific reports·2026

Related Experiment Video

Updated: May 17, 2026

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

Association between hemoglobin glycation index and cognitive function: Evidence in the elderly.

Liang Ge1, Yapeng Guo1, Xiangjun Xu1

  • 1Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu, China.

Plos One
|May 15, 2026
PubMed
Summary

Both low and high hemoglobin glycation index (HGI) levels are linked to cognitive decline in U.S. older adults. This suggests HGI may serve as an early indicator for cognitive impairment.

More Related Videos

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
06:21

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Published on: April 7, 2023

Analyzing the Permeability of the Blood-Brain Barrier by Microbial Traversal through Microvascular Endothelial Cells
06:26

Analyzing the Permeability of the Blood-Brain Barrier by Microbial Traversal through Microvascular Endothelial Cells

Published on: February 14, 2020

Related Experiment Videos

Last Updated: May 17, 2026

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
06:21

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Published on: April 7, 2023

Analyzing the Permeability of the Blood-Brain Barrier by Microbial Traversal through Microvascular Endothelial Cells
06:26

Analyzing the Permeability of the Blood-Brain Barrier by Microbial Traversal through Microvascular Endothelial Cells

Published on: February 14, 2020

Area of Science:

  • Gerontology
  • Neuroscience
  • Endocrinology

Background:

  • Cognitive impairment presents a significant public health challenge, particularly among older adults.
  • The hemoglobin glycation index (HGI) is a marker of glycemic control variability.
  • Understanding factors associated with cognitive decline is crucial for developing preventative strategies.

Purpose of the Study:

  • To investigate the association between hemoglobin glycation index (HGI) and cognitive function in U.S. older adults.
  • To determine if HGI levels correlate with performance on specific cognitive tests.

Main Methods:

  • Cross-sectional study using National Health and Nutrition Examination Survey (NHANES) data (2011-2014).
  • Cognitive function assessed using Digit Symbol Substitution Test (DSST), Animal Fluency Test (AFT), and CERAD cognitive battery.
  • Weighted linear regression models analyzed the association between HGI tertiles and cognitive scores, controlling for covariates.

Main Results:

  • A total of 1,406 older adults were included in the analysis.
  • Both the lowest and highest HGI tertiles were associated with poorer cognitive function compared to the middle tertile.
  • Specific associations included lower Z-scores and CERAD scores in the lowest HGI tertile, and decreased Z-scores and DSST scores in the highest HGI tertile, with notable differences between sexes and antidiabetic drug use.

Conclusions:

  • Both lower and higher hemoglobin glycation index (HGI) levels are significantly associated with cognitive decline in U.S. older adults.
  • Lower HGI is linked to impairments in learning and memory, while higher HGI is associated with executive function deficits.
  • Further longitudinal research is warranted to explore HGI's potential as an early warning sign for cognitive decline.