[Bioelement signature in the life cycle of the far north population: A cross-age analysis.]

The study establishes a direct link between population health and the specific biogeochemical conditions of the Far North, enabling the identification of key risk groups and facilitating the development of targeted, gender-oriented nutritional support programs to correct the identified elemental disbalances. Analysis of the dynamics of the elemental status (macroelements, microelements) among residents of Magadan in the context of age-related transformation, with the development of digital risk profiles and predictive models of disbalance. The elemental composition of hair in 1016 residents of Magadan of different genders 0-81 years was studied using atomic emission and mass spectrometry and inductively coupled argon plasma. Evaluation tables of bioelement disbalance at different stages of the life cycle were constructed. The study proposes a reinterpretation of pediatric data, interpreting «superretention» as an adaptive mechanism rather than excess. This shift in perspective transforms diagnostic approaches and prevents unnecessary medical interventions when the organism is capable of autonomous adaptation. Adolescents and young adults demonstrated a high prevalence of deficiency states, whereas middle-aged and elderly populations exhibited accumulation of essential elements (K, Mn, Se, Zn). Notably, excessive levels of these nutrients may contribute to age-related pathology similarly to deficiencies. The combined excess of K, Mn, Se, and Zn disrupts mineral homeostasis, triggering cascading metabolic disgomeostasis and multiorgan dysfunction that primarily manifests as life-threatening cardiac arrhythmias, with additional significant impacts on neurological and gastrointestinal systems. The elemental status population of the Far North exhibits distinct age and gender specificity, shaped by regional biogeochemical factors. The obtained data enable the identification of at-risk groups (adolescents, elderly women) and establish a foundation for long-term scientific programs aimed at understanding human adaptation mechanisms to specific environmental conditions. This understanding is critically important for planning sustainable development in these territories and preserving the health of future generations.