Mycoplasma, antibiotics in lay, and antimicrobial resistance (AMR)

C J Morrow1, R A Achari2, M Charles3

  • 1Bioproperties Pty. Ltd., Ringwood, Victoria, Australia; Asia-Pacific Centre for Animal Health, Melbourne Veterinary School, The University of Melbourne, Victoria, Australia.

Poultry Science
|May 15, 2026
PubMed

Insights

Antimicrobial resistance (AMR) is a growing human health concern due to antimicrobial misuse. Phasing out preventive treatments in intensive animal farming, particularly in poultry, is crucial to preserve antimicrobial benefits and combat resistance.

Area of Science:

  • Veterinary Medicine
  • Microbiology
  • Public Health

Background:

  • Antimicrobial resistance (AMR) poses a significant threat to human health, largely driven by the overuse of antimicrobials.
  • Preventive use of antimicrobials, especially in intensive animal agriculture, contributes to the development and spread of AMR.

Purpose of the Study:

  • To highlight the link between regular antimicrobial use in poultry production and the rise of AMR.
  • To explore alternative strategies for disease prevention in poultry to reduce reliance on antimicrobials.

Main Methods:

  • Review of evidence presented at a symposium concerning antimicrobial usage patterns in poultry.
  • Analysis of the impact of preventive antimicrobial treatments on bacterial resistance in poultry.

Main Results:

  • Regular antimicrobial use in poultry laying periods drives AMR in Mycoplasma gallisepticum and Mycoplasma synoviae.
  • Antimicrobial use also promotes resistance in chicken microbiota, including zoonotic bacteria.

Conclusions:

  • Phasing out preventive antimicrobial treatments in intensive animal production is essential.
  • Achieving Mycoplasma freedom or implementing live Mycoplasma vaccination can reduce antibiotic dependence in poultry.

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