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Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
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SMPD1 modulates malignant progress of osteosarcoma through ferroptosis pathway

Chong Guo1, Kaiqiong Liao2, Guanglong Chen1

  • 1Jiangxi Key Laboratory of Oncology, The Third Affiliated Hospital（the First Hospital of Nanchang), Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330008, China; Department of Orthopedics, The Third Affiliated Hospital（the First Hospital of Nanchang), Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330008, China; Medical Department of Graduate School, Nanchang University, Nanchang, Jiangxi 330006, China.

Tissue & Cell
|May 15, 2026
PubMed
Summary

Sphingomyelin phosphodiesterase 1 (SMPD1) silencing restricts osteosarcoma growth by enhancing ferroptosis. This molecular mechanism involves the ACSL4/LPCAT3/ALOX15 axis, offering potential new therapeutic targets for osteosarcoma.

Keywords:
ACSL4/LPCAT3/ALOX15FerroptosisOsteosarcomaSMPD1

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