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Updated: May 17, 2026

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
Gut Microbiota and Venous Thromboembolism: An Emerging Link
Angela Di Giorgio1, Claudia Carnuccio1, Elina Verrilli1
1Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Angiology and Noninvasive Vascular Diagnostics Unit, Department of Cardiovascular Sciences CUORE, Italy.
Abstract:
Venous thromboembolism (VTE), encompassing deep vein thrombosis (DVT) and pulmonary embolism (PE), remains a leading cause of morbidity and mortality worldwide. Emerging evidence implicates the gut microbiota as a significant contributor to systemic diseases, including thrombotic disorders. This mini-review synthesizes current knowledge on the role of gut microbiota in VTE pathogenesis. Dysbiosis, a disruption in microbial composition, has been associated with systemic inflammation, endothelial dysfunction, and heightened platelet activation, all of which contribute to a prothrombotic state. Although causal relationships are still being elucidated, accumulating data suggest that the gut microbiota modulates coagulation and venous thrombosis, potentially representing a modifiable target for VTE risk reduction.
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