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Perception Phenotypes in Difficult-to-Treat Asthma Based on Asthma Control Reported by Patients and Lung Function
Liuyu Wei1, Sabina Stanescu1, Matthew Harvey1
1School of Psychology, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, United Kingdom.
Summary
Asthma perception and lung function are often discordant in difficult asthma patients. Addressing poor adherence, COPD, obesity, and depression can improve asthma control and outcomes.
Area of Science:
- Pulmonology
- Clinical Psychology
Background:
- Asthma control and lung function are crucial for assessing asthma severity.
- Discordance between self-reported control and lung function suggests heterogeneity in difficult asthma perception.
Purpose of the Study:
- To classify asthma perception phenotypes using patient-reported control and lung function.
- To investigate associations between these phenotypes and clinical characteristics in difficult asthma.
Main Methods:
- 185 difficult asthma patients were classified into four phenotypes based on Asthma Control Questionnaire (ACQ-6) scores and spirometry.
- Statistical analyses included bivariate and multinomial logistic regression.
Main Results:
- Only 55% of patients had concordant asthma control and lung function.
- Poorer perceived asthma control correlated with lower quality of life, more depressive symptoms, and increased oral corticosteroid use.
- The most impaired phenotype (poor control and lung function) linked to male sex, low adherence, COPD, obesity, and depression.
Conclusions:
- Identified concordant and discordant asthma perception phenotypes in difficult asthma.
- Clinical relevance highlighted: addressing adherence, COPD, obesity, and depression is key for improving asthma outcomes.
- A holistic approach is recommended for better asthma control, lung function, and psychosocial well-being.
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