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Related Concept Videos

Traumatic Brain Injury l: Introduction01:28

Traumatic Brain Injury l: Introduction

DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...
Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...

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Related Experiment Video

Updated: May 17, 2026

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
09:49

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

Published on: January 20, 2023

The Relationship Between Age, Brain Structure, and Cognition in Chronic Traumatic Brain Injury.

Amber Ayton1, Jennie Ponsford1, Amelia J Hicks1

  • 1Monash-Epworth Rehabilitation Research Centre, School of Psychological Sciences, Monash University, Melbourne, VIC, Australia.

Neurorehabilitation and Neural Repair
|May 15, 2026
PubMed
Summary

Long-term traumatic brain injury (TBI) impacts brain structure and cognition, but these effects may lessen in older adults. TBI-related changes in the fornix and thalamus correlate with cognitive function, particularly verbal memory and processing speed.

Keywords:
MRIageingchronic outcomescognitionneuroimagingtraumatic brain injury

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Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury
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Published on: November 19, 2012

Related Experiment Videos

Last Updated: May 17, 2026

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
09:49

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

Published on: January 20, 2023

Modified Mouse Model of Repetitive Mild Traumatic Brain Injury Incorporating Thinned-Skull Window and Fluid Percussion
04:54

Modified Mouse Model of Repetitive Mild Traumatic Brain Injury Incorporating Thinned-Skull Window and Fluid Percussion

Published on: April 19, 2024

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury
10:59

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Published on: November 19, 2012

Area of Science:

  • Neuroscience
  • Gerontology
  • Traumatic Brain Injury Research

Background:

  • The long-term effects of traumatic brain injury (TBI) on the aging brain are not well understood.
  • Controlled studies are needed to investigate the interaction between TBI and aging.

Purpose of the Study:

  • To examine how chronic moderate-severe TBI and advancing age interact to affect brain structure and cognition.
  • To analyze adults aged 40-90 years who underwent inpatient rehabilitation.

Main Methods:

  • Cross-sectional study using magnetic resonance imaging (MRI) and neuropsychological data.
  • 123 individuals with chronic moderate-severe TBI and 74 matched non-TBI controls.
  • Analysis of cortical thickness, subcortical volume, and white matter integrity.

Main Results:

  • Both aging and TBI independently reduced structural integrity in several brain regions.
  • Age moderated TBI effects on fornix integrity and left thalamic volume, with reduced impact in older adults.
  • Reductions in the fornix and thalamus correlated with poorer verbal memory and processing speed.

Conclusions:

  • TBI and aging independently affect brain structure, but their interaction is specific to regions like the fornix and thalamus.
  • TBI-related structural changes in middle age diminished in later life, not accelerating typical age-related declines.
  • Age-dependent structural changes in the fornix and thalamus significantly impact cognitive performance, especially verbal memory and processing speed.