Transforming Psoriatic Disease Care Through Innovation and Real-World Data: GRAPPA 2025 Soapbox Highlights

Area of Science:

• Rheumatology
• Digital Health
• Public Health

Background:

• Psoriatic disease (PsD) management requires innovative approaches.
• Latin America faces challenges in PsD care delivery and data standardization.

Purpose of the Study:

• To highlight advancements in psoriatic disease care presented at the GRAPPA 2025 meeting.
• To showcase the potential of digital health tools and regional collaborations for improving PsD outcomes.

Main Methods:

• Presentation of the iPROLEPSIS project utilizing digital phenotyping and AI for psoriatic arthritis (PsA) monitoring.
• Consensus recommendations from REAL-PANLAR for establishing PsD Centers of Excellence in Latin America via a Delphi process.
• Summary of real-world evidence on biologic drug survival across Latin American countries.

Main Results:

• The iPROLEPSIS project showed high accuracy in detecting functional impairments using smartphone-based data.
• Two adaptable models for PsD Centers of Excellence were defined to reduce diagnostic delays and enhance collaboration.
• Significant variability in biologic drug survival and discontinuation predictors was observed across Latin American cohorts.

Conclusions:

• Digital biomarkers and personalized digital care ecosystems show promise for PsA management.
• Standardized frameworks and Centers of Excellence are crucial for equitable and effective PsD care in Latin America.
• Real-world evidence and regional registries are essential for understanding and improving biologic treatment outcomes.