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Updated: May 17, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

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Published on: September 9, 2012

Factor XIII Deficiency and Measurement.

Catherine Pauline M Hayward¹, Natalie Mathews²

¹Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Special Coagulation, Hamilton Regional Laboratory Medicine Program, Hamilton, Ontario, Canada.

Clinics in Laboratory Medicine

|May 15, 2026

Summary

Factor XIII (FXIII) deficiency causes bleeding and is more prevalent in acquired forms. Diagnosis requires specialized FXIII activity and antigen assays, not routine tests.

Keywords:

Blood coagulation disorders Blood coagulation factor inhibitor Consumption coagulopathy Factor XIII Factor XIII deficiency Fibrinogen Hemorrhagic disorders

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Last Updated: May 17, 2026

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Area of Science:

Hematology
Coagulation science

Background:

Factor XIII (FXIII) stabilizes fibrin clots through cross-linking.
Acquired FXIII deficiency is more common than inherited forms, causing significant bleeding risks.
Causes include consumptive coagulopathies, infections, liver dysfunction, and FXIII inhibitors.

Purpose of the Study:

To highlight the prevalence and causes of acquired Factor XIII deficiency.
To emphasize the diagnostic challenges and necessary assays for FXIII deficiency.

Main Methods:

Review of literature on Factor XIII deficiency.
Discussion of diagnostic assays, including quantitative FXIII activity and antigen assays.
Mention of Bethesda assay modifications for inhibitor detection.

Main Results:

Acquired FXIII deficiency is approximately 10 times more prevalent than inherited deficiency.
Routine coagulation tests do not detect FXIII deficiency.
Quantitative assays are essential for diagnosis.

Conclusions:

Factor XIII deficiency necessitates specialized diagnostic evaluation.
Understanding acquired FXIII deficiency is crucial for managing bleeding disorders.
Bethesda assay modifications aid in diagnosing acquired FXIII inhibitors.