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Updated: May 17, 2026

Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines
Published on: August 21, 2019
Radon and lung cancer
Edouard Auclin1, Maxime Janin2, Laura Mezquita3
1Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, Paris, France; Institut Bergonié, Bordeaux, France.
Abstract:
Lung cancer is the deadliest cancer in Europe and worldwide. While 80-90% of cases are linked to tobacco, other risk factors include occupational exposures, air pollution, and radon. Radon is a natural radioactive gas, odorless and colorless, produced by uranium decay. It accumulates mainly in poorly ventilated buildings, accounting for over 50% of total exposure. Radon exposure causes genomic damage (DNA mutations, breaks) and immune system dysfunction (chronic inflammation, immunosuppression), promoting lung carcinogenesis. Epidemiological studies show a clear link between radon exposure and lung cancer risk, with a 10-20% increased risk per 100Bq/m3 increment. This risk is independent of smoking but synergistic with it. Prevention focuses on building ventilation, sealing, and systematic radon measurement in high-risk areas. Legal thresholds exist (300Bq/m3 in France) but enforcement varies. Prospective studies, such as Bioradon, aim to clarify biological mechanisms and refine screening strategies.
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