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Updated: May 17, 2026
06:08
Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma
Published on: June 2, 2023
Association between ranitidine use and thyroid cancer based on FAERS and VigiAccess databases
Qingli Shen1, Zhonghua Fu1, Zhengchao Xia1
1Department of pharmacy, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, 450003, China.
Discover Oncology
|May 15, 2026
Summary
This study found a signal suggesting ranitidine use may be linked to thyroid cancer reports. Further research is needed, but caution and thyroid monitoring are advised for long-term ranitidine prescriptions.
Area of Science:
- Pharmacovigilance
- Drug Safety
- Oncology
Background:
- Ranitidine's potential carcinogenic risk is debated.
- The association between ranitidine and thyroid cancer is not well-established.
Purpose of the Study:
- To evaluate the disproportionality signal for thyroid cancer reporting linked to ranitidine.
- Utilize FDA Adverse Event Reporting System (FAERS) and VigiAccess databases.
Main Methods:
- Data mining and statistical analysis of ranitidine-associated thyroid cancer events in FAERS.
- Supplement findings with data from the VigiAccess database.
Main Results:
- A significant disproportionality signal was detected between ranitidine and thyroid cancer (ROR = 40.60).
- VigiAccess data provided corroborating evidence.
- Longer ranitidine exposure correlated with increased thyroid cancer reporting frequency.
Conclusions:
- Findings suggest a potential association between ranitidine use and thyroid cancer reporting.
- The signal warrants confirmation via prospective studies.
- Clinicians should exercise caution with long-term ranitidine use and consider thyroid monitoring.
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