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Updated: May 17, 2026

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Published on: September 12, 2019

USP43 Inhibits Intestinal Inflammation via TRAF4-mediated NF-κB Signaling.

Li Zhou1, Dongliang Li2, Yan Lv1

  • 1Center for Translational Medicine, The Affiliated Zhangjiagang Hospital of Soochow University, No. 68 West Jiyang Road, Suzhou, 215600, China.

Inflammation
|May 15, 2026
PubMed
Summary
This summary is machine-generated.

Ubiquitin-specific protease 43 (USP43) is reduced in ulcerative colitis (UC) and exacerbates inflammation. USP43 suppresses intestinal inflammation by inhibiting TRAF4-mediated NF-κB activation, revealing a new therapeutic target.

Keywords:
InflammationTRAF4/NF-κBUSP43Ulcerative colitis

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Published on: April 21, 2015

Area of Science:

  • Gastroenterology
  • Immunology
  • Molecular Biology

Background:

  • Ulcerative colitis (UC) is a chronic intestinal inflammatory disorder with unclear mechanisms.
  • Identifying novel molecular players is crucial for understanding UC pathogenesis.

Purpose of the Study:

  • To investigate the role of ubiquitin-specific protease 43 (USP43) in intestinal inflammation.
  • To elucidate the underlying molecular mechanisms of USP43 in regulating inflammatory responses.

Main Methods:

  • Integrated RNA-sequencing and proteomic analyses in a dextran sulfate sodium (DSS)-induced colitis model.
  • Assessment of USP43 expression in UC patients and experimental colitis.
  • In vitro studies using lipopolysaccharide (LPS)-stimulated RAW264.7 cells to evaluate USP43 function.
  • Analysis of the interaction between USP43, TRAF4, and NF-κB signaling pathway.

Main Results:

  • USP43 expression was significantly decreased in DSS-induced colitis and in UC patients.
  • USP43 deficiency exacerbated DSS-induced colitis severity.
  • USP43 inhibited NF-κB activation and proinflammatory cytokine production in LPS-treated cells.
  • USP43 deubiquitinates TRAF4, thereby suppressing NF-κB signaling.

Conclusions:

  • USP43 plays a protective role in intestinal inflammation.
  • The USP43/TRAF4 axis is a novel regulator of NF-κB signaling in the gut.
  • USP43 represents a potential therapeutic target for ulcerative colitis.